The Cognitive Protector Factor
By Dr. Tamara Kung, ND
As we age, physical changes are inevitable. Our hair turns silver, skin wrinkles, while memory and cognitive function diminish. There is growing concern throughout our life that as our bodies and mind age, our quality of life declines. But, there is great news! What we do in our earlier years can protect quality for the long run!
The most common brain change people notice is memory loss. According to the Centers for Disease Control and Prevention, the greatest risk factor for dementia is age. Alzheimer’s disease is the most common kind of dementia, accounting for up to 80% of cases.
Scientists are still uncovering the exact mechanisms for this, but recent research shows that a process called oxidative stress plays an important role for cognitive decline. According to a 2020 review published in Frontiers in Neuroscience, many studies have demonstrated “Intimate links between oxidative stress and cognitive dysfunction during aging and age-associated neuronal diseases.”
While the cure is yet to be found, scientists believe antioxidant intake may have a profound protective effect on the brain as people age. Here’s what you need to know about antioxidants and your brain, including how to protect your memory, cognitive acuity, and mood.
Antioxidants and Brain Health
Oxidative stress means that the oxygen that our bodies use for energy (yup the very stuff needed for life) can actually cause a little damage as a result of just being a functioning human. Think of the oxidation that happens on metals which leads to damage, aka. “Rust”. We call these damaging components of oxygen “free radicals”. Our bodies are smart organisms, and are well equipped with ways to scrub away rust or protect our body from accruing this damage. We naturally produce antioxidants with cool names like superoxide dismutase (SOD), and glutathione.
There are, however, external inputs of free radicals as well – think added sugars, fake foods, alcohol, air pollution, and cigarette smoking. When we add these in addition to our own internal generation of free radicals, this can quickly add up and tip the scales beyond what our body can naturally protect us from. This is what causes the characteristics of what we call aging and is what leads to disease. Aging in and of iteslf dosen’t mean physical and cognitive decline, but rather, it’s the increased accumulation of “rust” or oxidative stress.
Research suggests that the brain is particularly vulnerable to oxidative stress and increased free radicals are tied to the incidence of Alzheimer’s, anxiety, and depression.
Tipping the Scale in Your Favour
Antioxidants from real food contain additional compounds called carotenoids, flavonoids, and resveratrol, that act like our second wind of protection, our backup which helps prevent cells from damage by extinguishing excess free radicals. My previous article describes how to incorporate and find the highest sources of antioxidant rich foods. They are primarily from fruits, vegetables, whole grains, nuts, and legumes which is why unprocessed, Real Foods has been shown to prevent diseases of the brain.
A 2020 analysis published in the International Journal of Molecular Sciences concluded that antioxidants can target free radicals in the brain and lower the oxidative stress associated with neurodegenerative diseases. According to a 2022 study in Neurology, people with higher antioxidant concentration in their blood also have a lower dementia risk. Specifically, the cognitive function score of people who ate more flavenoids – the compound found in onions (especially red), berries, citrus fruits, soybeans, cherries, and apples – declined more slowly per decade than people who ate fewer.
Different types of antioxidants work in different ways. They can either limit the production of free radicals, or make them less toxic to the body and brain which is why a variety of different types of antioxidants are most protective.
Antioxidant protection slows down the rate of neuron damage, and may even prevent it, so neurons can communicate better, leading to improved mental acuity, focus and memory. Since oxidative stress is also linked with depression and anxiety, studies have been able to show that patients with major depression do also have a decreased level of vitamin C and E in their blood. A 2018 animal study found that resveratrol, an antioxidant found in grapes, blueberries, cranberries, cacao, and peanuts , may be an effective treatment for depression. In fact, several studies show that a diet plentiful in antioxidant rich fruits and vegetables has been correlated with lowered risk of depression and psychological distress.
Increasing the intake of plant antioxidants has been shown to result in improved mood in multiple populations even after a single blueberry & spinach shake or daily green tea!
How to Protect Your Brain
In clinical practice, I often have patients come in who are taking supplements like vitamin C, A, E as an attempt to amp up their antioxidant levels. However, the National Institutes of Health recommends caution when taking these isolated antioxidants at doses higher than would ever be found in nature and from whole foods. Some studies have found evidence of thyroid impairment and vitamin C inhibition with excessively high doses of isolated antioxidants that come in pill form. For this reason, I prefer to recommend eating Real Foods.
If you’re in a pinch, products like Younited are great for a grab and go option. Looking for quick sources of real foods can also come in powdered form which make it convenient to travel with or incorporate in under 5 minutes as part of your daily routine to make sure your bases are covered.
For example, with breakfast, enjoy a colourful fruit as a side or enjoy fruits as your dessert after your meals. If you’re having pasta, or a meal that’s looking like a pile of shades of beige, add some spinach, peppers, pesto, or beets to it to give it a face-lift and health boost.
The thought of getting older can be overwhelming. For some, age may seem so distant that you may not think much about it. Numerically increasing our years is not inherently harmful, and doesn’t necessarily mean a drastic breakdown and loss of quality of life – as we see in the Blue Zones.
No matter how old you are, now is the perfect time to begin routines that protect you for years to come. What you do in your 30’s, 40’s, 50’s will hit you in your 70’s and 80’s and 90s! The healthier you are at those younger ages, the healthier you are later in life.
References:
Franzoni et al., (2021). Oxidative stress and cognitive decline: The neuroprotective role of natural antioxidants. Frontiers in Neuroscience, 15(729757). doi: 10.3389/fnins
Ighodaro, O.H., Akinloye, O.A. (2018). First line defence antioxidants-superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPX): Their fundamental role in the entire antioxidant defence grid. Alexandria Journal of Medicine, 54(4), 287-293. Retrieved from https://www.sciencedirect.com/science/article/pii/S2090506817301550
Waheed Janabi A.H. et al., (2020): A promising nutraceutical approach against lifespan-shortening diseases. Iran Journal of Basic Medical Science. 23(2):140-153. doi: 10.22038/IJBMS.2019.35125.8353. PMID: 32405356; PMCID: PMC7211351.